methylprednisolone will lower the extent or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Lonafarnib could boost the AUC and peak concentration of CYP2C19 substrates. If coadministration unavoidable, check for adverse reactions and decrease the CYP2C19 substrate dose in accordance with it